Recurrent symmetrical drug-related intertriginous and flexural exanthema caused by different iodinated contrast media

Method A 76-year-old woman with the diagnostic suspicion of urinary lithiasis, was subjected to a CT scan with an unknown ICM. Forty-eight hours after the CT scan was carried out, she developed an erythema in both axillae, inframammary folds, cubital and popliteal fossae, such as gluteal and inguinal area, without systemic symptoms. She was treated with methylprednisolone and she began to improve one week later. The patient had no previous history of drug hypersensitivity and she had tolerated ICM six years before. She was referred to our Drug Allergy Unit for study, where epicutaneous and single-blind intravenous controlled challenge tests were performed.